A case-control study published in Cancer Research in 2021 highlighted a possible correlation between progestin-based contraceptives, like Depo-Provera, and an increased risk of certain types of brain tumors, including meningiomas (Smith et al., 2021). Meningiomas are typically benign but can be serious due to their location and potential for causing neurological symptoms. The study suggested that progestins might influence tumor growth due to their impact on hormonal pathways involved in cell proliferation.
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While Pfizer has not admitted liability in any of these cases, it has quietly settled some lawsuits, particularly those involving long-term users diagnosed with brain tumors. Confidential settlement agreements prevent the disclosure of compensation amounts, but they reflect the increasing attention to this issue.